The increase in anal cancer incidence in the United States between 1980 and 2005 was greatly influenced by HIV infections in males, but not females

Anal cancer in the United States is rare, with an estimated 6,230 cases in 2012, but incidence has been steadily increasing in the general population since 1940. HIV infection is significantly associated with an increase in anal cancer risk, and anal cancer is the fourth most common cancer found in HIV-infected people. However, it has been unclear the degree to which anal cancer cases occurring among people with HIV has affected anal cancer incidence in the general population. Researchers have found that of the 20,533 anal cancer cases between 1980 and 2005, an estimated 1,665 individuals were infected with HIV. In 2001-2005, the most recent time period examined, 1.2% of women with anal cancer and 28.4% of men with anal cancer were HIV-positive. During 1980-2005, HIV infection did not have an impact on the increasing anal cancer incidence rates among women, but HIV had a strong impact on the increasing anal cancer incidence rates among men.