Europeans are among the most sugar-sensitive people in the world, a new genetic analysis concludes

The vast majority of people in Britain, France, Italy and Russia boast a tandem of genetic variations in a sugar-sensing gene that allows them to detect trace levels of sweetness. Around the world, populations that live at northern latitudes carry these genetic variations at far higher frequencies than tropical-living peoples, says Dennis Drayna, a geneticist at the National Institute on Deafness and Other Communication Disorders in Bethesda, Maryland. His team presented 144 Europeans, Asians and Africans with nine solutions containing varying amounts of table sugar – sucrose – in amounts varying from 0% to 4%. Volunteers arranged the solutions in order of their perceived sweetness numerous times, and from these, Drayna's team calculated a sucrose sensitivity score for each person. When the researchers correlated the scores with variations in two sugar-sensing genes, TAS1R3 and TAS1R2, they found two variants just outside of the TAS1R3 gene that seemed to predict their volunteer's scores. This puzzled Drayna because TAS1R2 is chock-full of single DNA letter differences between people, and research on bitter taste genes suggested that such mutations – which change the shape of the receptor – underlie these differences. Instead, the two variations near TAS1R3 probably determine how much of a receptor protein is produced by the taste buds, Drayna says. Tests showed that the variations most common in Europeans crank up the expression of TAS1R3. Although the gene variants were commonest in Europeans, they were also widespread in Japanese, Palestinian, Han Chinese and other Middle Eastern and Asian populations. Low-sensitivity variations were most prevalent among the several different African populations that the team examined.