Wednesday, October 22, 2014

The male Y chromosome may have a role in prolonging men's lives and fighting cancer, scientists have said

Research into 1,153 elderly men at the University of Sweden found those who had lost part of their Y chromosome died on average 5.5 years earlier than those who had not. Women live on average 7.5 years longer than men in Europe and the reasons behind this are not fully known. Scientists assessed how many blood cells had age-related loss of the Y chromosome (LOY) through blood tests in the men, aged between 70 and 84. Men with a "significant amount" of loss died earlier, said researchers. LOY was associated with general risk of death in 637 out of the group of men and risk of death due to non-blood related cancer in 132 of the cases. The co author of the study, Jan Dumanski from Uppsala University in Sweden, said: "Many people think the Y chromosome only contains genes involved in sex determination and sperm production. In fact, these genes have other important functions, such as possibly playing a role in preventing tumors." The study said that Y chromosome genes were not expressed when LOY occurred, meaning its potential role in tumor prevention could be reduced. It said that LOY in blood cells was associated with many different cancers, including those outside the blood system. Researchers said that this could be because Y chromosome genes enabled blood cells to help with immuno-surveillance, where the immune system detected and killed tumor cells to prevent cancer. The finding means blood tests looking at the state of the Y chromosome could help predict a man's risk of cancer, say the authors.

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