Voltaire — To learn who rules over you, simply find out who you are not allowed to criticize
Thursday, January 8, 2015
New research provides insights into the ties between certain genetic variants and kidney disease in African Americans
African Americans have a 4-fold increased risk for chronic kidney disease compared with European Americans. Recent work from several research groups has shown that much of this risk is due to genetic variations in a gene called apolipoprotein L1 (APOL1), which creates a protein that is a component of HDL, or good cholesterol. These variants arose tens of thousands of years ago in sub-Saharan Africa, and so are present in individuals who have recent sub-Saharan African ancestry. Approximately 5 million African Americans carry APOL1 risk variants, placing them at increased risk for kidney disease. The investigators found that 72% of self-identified African Americans in the study had APOL1 risk variants.
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