The mutation responsible for the alcohol flush reaction in people of Asian descent may have occurred following the domestication of rice

Researchers traced the history of the version of the gene responsible, finding that the ADH1B*47His allele appeared around the same time that rice was first cultivated in southern China. Bing Su, from the Chinese Academy of Sciences, China, worked with a team of researchers to study 38 populations (2,275 individuals) including Han Chinese, Tibetan and other ethnic populations across China. He said, "Our molecular dating suggests that the emergence of the ADH1B*47His allele occurred about 10,000-7,000 years ago. The geographic distribution of the allele in East Asia is also consistent with the unearthed culture relic sites of rice domestication in China, suggesting that distribution of the alcohol flush mutation can be explained by the origin and expansion of the Neolithic rice culture. This is one of the few cases reported demonstrating the genetic adaptation of human populations to the dramatic changes in agriculture and diet during Neolithic times".