Wednesday, September 21, 2011

Patients with a high degree of African ancestry had a greater incidence of high-risk neuroblastoma and poorer outcomes

Children with a higher degree of African ancestry had increased rates of high-risk disease and lower survival rates following chemotherapy. This indicates that African ancestors may have passed along common genetic variants that are associated with the development of the aggressive form of neuroblastoma and perhaps a relative intrinsic chemotherapy resistance that is associated with the observed inferior outcomes.

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