Men with Y-chromosome haplogroup I have a 50% greater risk of developing heart disease

A study found that men in haplogroup I have lower numbers of copies of two important Y chromosome genes in macrophages - the type of white blood cells involved in both defence against infections and atherosclerosis. Specifically, men with haplogroup I were shown to have decreased expression of 2 genes: the ubiquitously transcribed tetratricopeptide repeat, Y-linked gene (UTY) and protein kinase, Y-linked, pseudogene (PRKY) in macrophages.